Dynamic changes in circulating PD-1+CD8+ T lymphocytes for predicting treatment response to PD-1 blockade in patients with non-small-cell lung cancer

The predictive value of immune monitoring with circulating CD8+ T lymphocytes for treatment response to programmed cell death protein 1 (PD-1) inhibitors has not been explored in non-small-cell lung cancer (NSCLC), prompting us to investigate whether dynamic changes in PD-1+CD8+ T lymphocytes have p...

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Veröffentlicht in:	European journal of cancer (1990) 2021-01, Vol.143, p.113-126
Hauptverfasser:	Kim, Chang Gon, Hong, Min Hee, Kim, Kyung Hwan, Seo, In-Ho, Ahn, Beung-Chul, Pyo, Kyoung-Ho, Synn, Chun-Bong, Yoon, Hong In, Shim, Hyo Sup, Lee, Yong Il, Choi, Seong Jin, Lee, Yun Jeong, Kim, Ellen Janine, Kim, Youngun, Kwak, Jeong-Eun, Jung, Jaehyung, Park, Su-Hyung, Paik, Soonmyung, Shin, Eui-Cheol, Kim, Hye Ryun
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Anti-programmed cell death-1 treatment Antigens Apoptosis Biomarker Carcinoma, Non-Small-Cell Lung - drug therapy CD8 antigen CD8+ T lymphocytes CD8-Positive T-Lymphocytes - metabolism Cell death Female Flow cytometry Humans Immune Checkpoint Inhibitors - pharmacology Immune Checkpoint Inhibitors - therapeutic use Inhibitors Lung cancer Lung Neoplasms - drug therapy Lymphocytes Lymphocytes T Male Memory cells Metastases Middle Aged Non-small cell lung carcinoma Non-small-cell lung cancer Patients PD-1 protein Peripheral blood Phenotyping Programmed Cell Death 1 Receptor - antagonists & inhibitors Small cell lung carcinoma Subgroups Survival Tumors
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