Improving the drug dissolution profile of poorly aqueous soluble lovastatin using hydrophilic polymers by solid dispersion and physical mixing techniques

[...]this approach of SD technique utilizing the above-mentioned carriers could be employed as a substantial formulation strategy to enhance the in vitro dissolution rate which, in turn, may improve the oral bioavailability of the water-insoluble drugs. [...]dissolution is considered as the rate determining step especially for Class II drugs which show high permeability but low solubility. Several approaches have been adopted to rise the dissolution rate of poorly soluble drugs including physical, chemical, and other modifications or techniques such as particle size reduction, salt formation, pro-drugs, pH adjustments, micro-emulsion, complexation, cosolvency, and nanocrystallization. Instruments such as dissolution tester, ultraviolet-visible spectroscopy (UV-VIS), electronic balance, desiccators, mortar/pestle, and scanning electron microscopy (SEM) were used in the analyses and formulation preparations available in Pharmaceutical Technology Laboratory and CARS, University of Dhaka.