Poly (β‐amino esters) based potential drug delivery and targeting polymer; an overview and perspectives (review)

[Display omitted] •Poly β-amino esters have drawn extensive attention in plasmid delivery.•The current state of knowledge and issues on poly β-amino esters are reviewed.•Strategies to improve stability and efficiency and future directions are proposed. Poly(β-amino ester)s (PβAE)s are considered as the most potent alternative to viral vectors, which has been increasingly proposed for targeting gene delivery, because of their excellent transfection performance. The self-assembled nanoparticles formed from interaction with nucleic acids showed good biodegradable and hydrophilic nature, which make PβAE superior over other polycationic polymers. PβAEs exhibit different kinetic profiles and tunable charge density, which can be fabricated using a diverse library of building blocks and binding various conjugates to improve transfection efficiency. The rational designing of PβAE is a critical step to achieve various requirements of gene delivery, anticancer and antimicrobial drug delivery, and nanochaperones. This review presents a revised recapitulation of the synthesis protocols, formulation aspects, and biomedical applications of PβAEs. Within each of these titles, a critical analysis of the design principles and strategies along with examples, opportunities, and challenges are discussed.