Vitamin K protects against 7,12‐dimethylbenz(A)anthracene induced hepatotoxicity in Wistar rats

Humans are daily exposed to 7,12‐dimethylbenz(a)anthracene (DMBA), a well known polycyclic aromatic hydrocarbons (PAH). This study investigated the role of dietary intake of Vitamin K (VK), a polyphenolic compound, with potential antioxidative properties, against DMBA‐induced hepatotoxicity. Sixty e...

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Veröffentlicht in:	Environmental toxicology 2021-03, Vol.36 (3), p.362-373
Hauptverfasser:	Dosumu, Oluwatosin Adebisi, Rotimi, Solomon Oladapo, Adeleye, Oluwagbemiga Olanrewaju, Akamo, Adio Jamiu, Osinuga, Kehinde Temitope, Taiwo, Odunayo Anthonia, Omotosho, Oluwatosin Oyebola, Sani, Latifah Oyefoluke
Format:	Artikel
Sprache:	eng
Schlagworte:	7,12‐dimethylbenz(a)anthracene 9,10-Dimethyl-1,2-benzanthracene 9,10-Dimethyl-1,2-benzanthracene - toxicity Alanine Alkaline phosphatase Animals Anthracene Anthracenes antioxidant enzymes Antioxidants - pharmacology Aromatic compounds Aromatic hydrocarbons Ascorbic Acid Biomarkers Body weight Catalase Catalase - metabolism Chemical and Drug Induced Liver Injury - prevention & control Colonies Colony-stimulating factor Damage Diet Dietary intake Food intake Glutathione Glutathione - metabolism Glutathione Peroxidase Glutathione Transferase Granulocyte-macrophage colony-stimulating factor hepatoprotective Hepatotoxicity Inflammation inflammatory markers Ingestion Interleukins L-Lactate dehydrogenase Lactate Lactate dehydrogenase Lactic acid Leukocytes (granulocytic) Liver Liver - metabolism Macrophages Male Malondialdehyde Nitric oxide Oral administration Oxidative Stress - drug effects Peroxidase Phosphatase Phylloquinone Polycyclic aromatic hydrocarbons Rats Rats, Wistar Serum Superoxide dismutase Superoxide Dismutase - metabolism Vitamin E Vitamin K Vitamin K - pharmacology Vitamins
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Zusammenfassung:	Humans are daily exposed to 7,12‐dimethylbenz(a)anthracene (DMBA), a well known polycyclic aromatic hydrocarbons (PAH). This study investigated the role of dietary intake of Vitamin K (VK), a polyphenolic compound, with potential antioxidative properties, against DMBA‐induced hepatotoxicity. Sixty experimental animals (120‐150 g) were divided into six groups (A‐F): Control, DMBA (80 mg/kg bw) only, VK (0.00 g/10 kg) diet only, VK (7.5 g/10 kg) diet only, DMBA + VK (0.0 g/10 kg) diet and DMBA + VK (7.5 g/10 kg) diet. Single oral administration of DMBA (80 mg/kg body weight) to Wistar rats resulted in hepatic damage after 16 weeks. DMBA significantly (P
ISSN:	1520-4081 1522-7278
DOI:	10.1002/tox.23042