Promiscuity of an unrelated anthrol reductase of Talaromyces islandicus WF-38-12

Promiscuity of an unrelated anthrol reductase of Talaromyces islandicus WF-38-12

An anthrol reductase of Talaromyces islandicus WF-38-12 (ARti-2) from an unrelated biosynthetic gene cluster (BGC) has been identified and characterized. It catalyses the NADPH-dependent reduction of anthrols (hydroanthraquinones), estrone and a naphthol with high stereo- and regioselectivity. The r...

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Veröffentlicht in:Catalysis science & technology 2021-01, Vol.11 (2), p.474-478
Hauptverfasser: Singh, Shailesh Kumar, Rajput, Anshul, De, Arijit, Chakraborti, Tapati, Husain, Syed Masood
Format: Artikel
Sprache:eng
Schlagworte:
Biosynthesis
Naphthol
Oxidation
Reductases
Regioselectivity
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Zusammenfassung:An anthrol reductase of Talaromyces islandicus WF-38-12 (ARti-2) from an unrelated biosynthetic gene cluster (BGC) has been identified and characterized. It catalyses the NADPH-dependent reduction of anthrols (hydroanthraquinones), estrone and a naphthol with high stereo- and regioselectivity. The role of ARti-2, the CRG89872.1 gene of the same BGC and non-enzymatic oxidation in the biosynthesis of (−)-flavoskyrin has been proposed.
ISSN:2044-4753
2044-4761
DOI:10.1039/D0CY02148B