Inhaled Treprostinil in Pulmonary Hypertension Due to Interstitial Lung Disease

Patients with pulmonary hypertension due to interstitial lung disease were randomly assigned to inhaled treprostinil or placebo. At 16 weeks, there was a significant improvement in exercise capacity with inhaled treprostinil as compared with placebo as assessed by a 6-minute walk test.

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Bibliographische Detailangaben
Veröffentlicht in:	The New England journal of medicine 2021-01, Vol.384 (4), p.325-334
Hauptverfasser:	Waxman, Aaron, Restrepo-Jaramillo, Ricardo, Thenappan, Thenappan, Ravichandran, Ashwin, Engel, Peter, Bajwa, Abubakr, Allen, Roblee, Feldman, Jeremy, Argula, Rahul, Smith, Peter, Rollins, Kristan, Deng, Chunqin, Peterson, Leigh, Bell, Heidi, Tapson, Victor, Nathan, Steven D
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Inhalation Adult Adverse events Aged Aged, 80 and over Antihypertensive Agents - adverse effects Antihypertensive Agents - therapeutic use Brain natriuretic peptide Catheterization Clinical trials Cough Diarrhea Double-Blind Method Drug dosages Dyspnea Epoprostenol - adverse effects Epoprostenol - analogs & derivatives Epoprostenol - therapeutic use Exercise Tolerance - drug effects Female Humans Hypertension Hypertension, Pulmonary - drug therapy Hypertension, Pulmonary - etiology Hypertension, Pulmonary - physiopathology Laboratories Least-Squares Analysis Lung diseases Lung Diseases, Interstitial - complications Male Middle Aged Nausea Patients Placebos Pulmonary hypertension Pulse oximetry Quality of Life Respiration Statistical analysis Walk Test
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Beschreibung
Zusammenfassung:	Patients with pulmonary hypertension due to interstitial lung disease were randomly assigned to inhaled treprostinil or placebo. At 16 weeks, there was a significant improvement in exercise capacity with inhaled treprostinil as compared with placebo as assessed by a 6-minute walk test.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa2008470