Synthesis of Low-Molecular-Weight Antibacterial Peptide Mimetics Based on Dialkyl- and Diacylamines

This study is aimed at creating a number of derivatives of natural amino acids based on dioctylamine and diethanolamine diesters with potential antibacterial activity. Simple and universal schemes of the synthesis allow them to be used for obtaining a series of samples in the preparative quantities necessary for the implementation of physiochemical and biochemical studies. The synthesized sample based on glycyldioctylamide shows a promising level of antimicrobial activity (MIC) against Gram-positive and Gram-negative bacteria.