Micronization of Levofloxacin Using the RESS Method

The antibacterial drug levofloxacin (LF) is micronized by the Rapid Expansion of the Supercritical Solution (RESS) method to obtain microparticles with a high level of bioavailability. Ethanol is used as a cosolvent to increase the solubility of LF in supercritical carbon dioxide. Spherical LF micro...

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Veröffentlicht in:	Russian journal of physical chemistry. B 2020-12, Vol.14 (7), p.1225-1228
Hauptverfasser:	Antonov, E. N., Krotova, L. I., Mishakov, G. V., Popov, V. K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiinfectives and antibacterials Bioavailability Carbon dioxide Chemistry Chemistry and Materials Science Ethanol Microparticles Physical Chemistry
Online-Zugang:	Volltext
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Zusammenfassung:	The antibacterial drug levofloxacin (LF) is micronized by the Rapid Expansion of the Supercritical Solution (RESS) method to obtain microparticles with a high level of bioavailability. Ethanol is used as a cosolvent to increase the solubility of LF in supercritical carbon dioxide. Spherical LF microparticles with the characteristic size of
ISSN:	1990-7931 1990-7923
DOI:	10.1134/S1990793120070210