O49 Dietary triggers of colonic inflammation following exclusive enteral nutrition treatment in children with Crohn’s disease

IntroductionExclusive enteral nutrition (EEN) ameliorates gut inflammation in children with Crohn’s disease (CD). We have previously described the rapid rise in faecal calprotectin levels (FC) when children with CD return to their habitual diet after EEN treatment.1 We explored dietary triggers of CD relapse by performing dietary assessment and measuring faecal food biomarkers in children with CD during early food reintroduction.MethodsCombination of clinical remission post EEN (weighted Paediatric Crohn’s Disease Activity Index 500 mg/kg/>35%), was used to define the patient group. All patients provided 3-day estimated weight food diaries and a faecal sample. Patients were divided equally for statistical analysis purposes in two groups; above (Group 1) and below (Group 2) the median FC concentration at food reintroduction [900 mg/kg (341, 1,243)]. Nutrient and food group analysis was performed with WinDiets 10. Faecal short chain fatty acids, gluten immunogenic peptide and starch were measured as proxy of fibre, gluten and malabsorbed/resistant starch.Results14 children provided a FC sample within 21 (15, 51) days post EEN. Classification of patients in the two groups resulted in significantly different FC values: Group 1: 1181 mg/kg (1024, 1781) vs Group 2: 411 mg/kg (130, 651) (p