P132 The role of Vitamin D in pulmonary sarcoidosis and inflammation

Introduction and ObjectivesSarcoidosis is a multisystem disease of unknown aetiology characterized by a Th1 granulomatous immune response. Granuloma formation has been linked to a failure of the innate immune system, which could be related to a deficiency in vitamin D. Previous studies have documented low levels of vitamin D in patients with sarcoidosis. We aimed to explore the role of vitamin D in sarcoidosis and its relationship to biomarkers of disease activity and severity.MethodsBaseline demography, mode of presentation, Scadding CXR stage and need for treatment was recorded for 184 patients. Additional data including biochemical markers of disease activity and serum vitamin D levels were performed in 66 patients within a 4-week study period. Disease activity was assessed using lymphocyte trend, inflammatory markers, LFT, serum ACE and IgG, physiological and radiological measures as well as the need for treatment. Vitamin D levels were grouped into ‘sufficient’ (>50 nmol/L) and ‘insufficient or deficient’ (