Neurochemistry of the Kölliker‐Fuse nucleus from a respiratory perspective
The Kölliker‐Fuse nucleus (KF) is a functionally distinct component of the parabrachial complex, located in the dorsolateral pons of mammals. The KF has a major role in respiration and upper airway control. A comprehensive understanding of the KF and its contributions to respiratory function and dys...
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Veröffentlicht in: | Journal of neurochemistry 2021-01, Vol.156 (1), p.16-37 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | The Kölliker‐Fuse nucleus (KF) is a functionally distinct component of the parabrachial complex, located in the dorsolateral pons of mammals. The KF has a major role in respiration and upper airway control. A comprehensive understanding of the KF and its contributions to respiratory function and dysfunction requires an appreciation for its neurochemical characteristics. The goal of this review is to summarize the diverse neurochemical composition of the KF, focusing on the neurotransmitters, neuromodulators, and neuropeptides present. We also include a description of the receptors expressed on KF neurons and transporters involved in each system, as well as their putative roles in respiratory physiology. Finally, we provide a short section reviewing the literature regarding neurochemical changes in the KF in the context of respiratory dysfunction observed in SIDS and Rett syndrome. By over‐viewing the current literature on the neurochemical composition of the KF, this review will serve to aid a wide range of topics in the future research into the neural control of respiration in health and disease.
The Kölliker‐Fuse nucleus (KF) plays an important role in respiration and upper airway control. The purpose of this review is to summarize the neurochemical composition of the KF, discussing the neurotransmitters, neuromodulators, and neuropeptides present. We also describe the receptors and transporters involved in each system, and provide a summary of their roles in the control of breathing. In addition, we briefly discuss the neurochemical changes in the KF in SIDS and Rett syndrome. This review will serve to support a wide range of topics in the future research into the neural control of breathing in health and disease. |
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ISSN: | 0022-3042 1471-4159 |
DOI: | 10.1111/jnc.15041 |