Choroidal changes in mild Alzheimer's disease patients as a biomarker of cerebral amyloid angiopathy

Purpose Alzheimer's disease (AD) is a progressive neurodegeneration in which vascular changes occur that constitute cerebral amyloid angiopathy. Recently, alterations and deposits have been discovered in the retinas and choroids of patients with AD that correlate with the evolution of the disea...

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Veröffentlicht in:Acta ophthalmologica (Oxford, England) England), 2021-01, Vol.99 (S265), p.n/a
Hauptverfasser: Salobrar‐Garcia, Elena, López‐Cuenca, Inés, Fernández‐Albarral, José A., Lozano, María Pilar Rojas, De Hoz, Rosa, Ramirez, Ana Isabel, Mendez‐Hernandez, Carmen, Wang, Surina, Garcia‐Feijoo, Julian, Corral, Juan José Salazar, Manuel Ramirez, Jose
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Sprache:eng
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Zusammenfassung:Purpose Alzheimer's disease (AD) is a progressive neurodegeneration in which vascular changes occur that constitute cerebral amyloid angiopathy. Recently, alterations and deposits have been discovered in the retinas and choroids of patients with AD that correlate with the evolution of the disease. The development of new techniques for the study of ocular vascularization, Laguna ONhE and Angio‐optical coherence tomography (OCTA), non‐invasive and non‐contrast tests, allow us to study ocular vascular alterations caused by AD. Methods Seventeen patients with mild AD (mAD) and 49 healthy controls, all without ophthalmological diseases after a complete eye examination, were studied for haemoglobin (Hb) coefficient in the optic nerve head by Laguna ONhE, as well as choroid thickness and foveal avascular zone (FAZ) of the retina by OCTA. For statistical analysis, the Mann‐Whitney test was applied with the SPSS 22.00 program. Results The Mini Mental State Examination of the mAD patients was 24.00 ± 5.32, while the control group was 29.40 ± 1.83, being the difference significant (p 
ISSN:1755-375X
1755-3768
DOI:10.1111/aos.0134