Fabrication of polyhydroxy butyric acid–Gelatin blended nanofibrous matrix integrated with silver sulfadiazine as an alternate wound dressing for treating burns

[Display omitted] •Nanofibrous PHB-Gelatin matrix incorporated with Silver sulfadiazine was fabricated.•Controlled release of SSD till 72 h aids in prevention of secondary infection at wound site.•Sustained and prolonged release of SSD thereby reducing the dressing frequency.•SSD loaded matrix exhibited inhibition against P. aeruginosa, E. coli and S. aureus.•Nanofiber matrix showed good cell adhesion and proliferation of NIH 3T3 fibroblast.•The nanofibrous matrix support faster re-epithelialization and healing of burn wounds. The design of an alternate wound dressing material is necessary to overcome difficulties such as less contact time formulations, more extended hospitalization, and prevent secondary infection. Herein, we report the electrospinning of Polyhydroxy butyric acid (PHB) -Gelatin (70:30) nanofibrous matrix loaded with Silver sulfadiazine (SSD) (0.2% w/v) to act as a carrier to prevent infection at second degree burn wound site. The nanofibrous matrix proves to facilitate good stability against exudates absorption and oxygen permeability. The controlled delivery of the SSD tends to reduce the dressing frequency. The biocompatibility and cell adhesion were assessed with NIH 3T3 fibroblast. The in vivo burn wounds supported enhanced re-epithelialization and MMP-9 production exhibited with fast healing of wound from day 18. Thus, the nanofibrous scaffold serves as an alternate wound dressing material in treating burns by reducing dressing frequency and lessening the adverse effects of antibiotics by its limited usage.