A cross-platform approach identifies genetic regulators of human metabolism and health

In cross-platform analyses of 174 metabolites, we identify 499 associations ( P

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Veröffentlicht in:	Nature genetics 2021-01, Vol.53 (1), p.54-64
Hauptverfasser:	Lotta, Luca A., Pietzner, Maik, Stewart, Isobel D., Wittemans, Laura B. L., Li, Chen, Bonelli, Roberto, Raffler, Johannes, Biggs, Emma K., Oliver-Williams, Clare, Auyeung, Victoria P. W., Luan, Jian’an, Wheeler, Eleanor, Paige, Ellie, Surendran, Praveen, Michelotti, Gregory A., Scott, Robert A., Burgess, Stephen, Zuber, Verena, Sanderson, Eleanor, Koulman, Albert, Imamura, Fumiaki, Forouhi, Nita G., Khaw, Kay-Tee, Griffin, Julian L., Wood, Angela M., Kastenmüller, Gabi, Danesh, John, Butterworth, Adam S., Gribble, Fiona M., Reimann, Frank, Bahlo, Melanie, Fauman, Eric, Wareham, Nicholas J., Langenberg, Claudia
Format:	Artikel
Sprache:	eng
Schlagworte:	45 45/43 631/208/205 692/308/575 Agriculture Animal Genetics and Genomics Arrestin Biomedical and Life Sciences Biomedicine Body mass index Body size Cancer Research Citrulline Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - genetics Eye Diseases - genetics Gene Frequency - genetics Gene Function Gene loci Genetic aspects Genetic Loci Genetic Pleiotropy Genetic regulation Genome, Human Genomes Glucagon-Like Peptide-2 Receptor - genetics Glycine - metabolism Health Health aspects Heterogeneity Human Genetics Humans Linear Models Mendelian Randomization Analysis Metabolism Metabolism - genetics Metabolism, Inborn Errors - genetics Metabolites Metabolome - genetics Mutation, Missense - genetics Phenotype Pleiotropy Polymorphism, Single Nucleotide - genetics Principal components analysis Regulators Retinal Telangiectasis - genetics Sample Size Serine Serine - metabolism
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Beschreibung
Zusammenfassung:	In cross-platform analyses of 174 metabolites, we identify 499 associations ( P
ISSN:	1061-4036 1546-1718
DOI:	10.1038/s41588-020-00751-5