Total Parietal Peritonectomy Can Be Performed with Acceptable Morbidity for Patients with Advanced Ovarian Cancer After Neoadjuvant Chemotherapy: Results From a Prospective Multi-centric Study

Background Total parietal peritonectomy (TPP) removes areas of “normal-appearing” parietal peritoneum bearing microscopic residual disease and has the potential to improve survival of patients undergoing interval cytoreductive surgery (CRS) for advanced serous epithelial ovarian cancer. This report presents the morbidity outcomes for the first 50 patients enrolled in TORPEDO (CTRI/2018/12/016789), a prospective study. Methods All the patients underwent a TPP during interval CRS. A surgical protocol that includes a description of the boundaries for each of the five peritonectomies was followed. The common toxicology criteria for adverse events (CTCAE) classification was used to record 90-day morbidity and mortality. Results The median Peritoneal Cancer Index (PCI) for 50 patients was 15 (range, 5–37). A complete cytoreduction (CC-0 resection) was obtained in 80%, a CC-1 resection in 16%. A bowel resection was performed in 70% of the patients. Grade 3 or 4 complications were seen in 11 patients (22%), and one patient died within 90 days after surgery due to intraperitoneal hemorrhage. The most common complications were postoperative fluid collection requiring aspiration ( n = 5), intraperitoneal hemorrhage ( n = 2), abdominal wound dehiscence ( n = 2), pseudo-obstruction ( n = 1), urinary sepsis ( n = 2), and ileostomy-related complications ( n = 2). No bowel fistulas or anastomotic leaks occurred. Microscopic disease in ‘normal appearing’ peritoneum adjacent to tumor nodules was observed in 46% of the patients, and in regions given a lesion score of 0 in 34%. The parietal peritoneal regions (0–8) had a higher incidence of residual disease ( p