Synthesis of ɣ-glutamyl β-cyanoalanine precursor

Synthesis of ɣ-glutamyl β-cyanoalanine precursor

The synthesis of precursors of neurotoxic ɣ-glutamyl β-cyanoalanine was developed starting from L-Serine via through the preparation of b-cyanoalanine and glutamyl units. Coupling of these two intermediates gave methyl ester of ɣ-glutamyl β-cyanoalanine precursor.

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Bibliographische Detailangaben
Veröffentlicht in:Organic communications 2020-12, Vol.13 (4), p.202-206
Hauptverfasser: Ün, Şule, Altundas, Ramazan, Goren, Ahmet C
Format: Artikel
Sprache:eng
Schlagworte:
Intermediates
L-Serine
Neurotoxicity
Precursors
Synthesis
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Beschreibung
Zusammenfassung:The synthesis of precursors of neurotoxic ɣ-glutamyl β-cyanoalanine was developed starting from L-Serine via through the preparation of b-cyanoalanine and glutamyl units. Coupling of these two intermediates gave methyl ester of ɣ-glutamyl β-cyanoalanine precursor.
ISSN:1307-6175
1307-6175
DOI:10.25135/acg.oc.89.20.05.1660