Using the exposome to address gene–environment interactions in kidney disease

Using the exposome to address gene–environment interactions in kidney disease

New exposome-based approaches permit omic-scale characterization of the non-genetic contributors to kidney disease. High-resolution mass spectrometry analysis of plasma and urine samples captures a wide range of exogenous and endogenous metabolites that can be used in combination with genetic risk f...

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Veröffentlicht in:Nature reviews. Nephrology 2020-11, Vol.16 (11), p.621-622
Hauptverfasser: Dupre, Tess V., Schnellmann, Rick G., Miller, Gary W.
Format: Artikel
Sprache:eng
Schlagworte:
631/1647/320
692/4022/272
Acids
Biomarkers
Biomarkers - analysis
Body weight
Cadmium
Chromatography
Comment
Disease Susceptibility
Environmental health
Exposome
Gene-Environment Interaction
Genomes
Health aspects
Health risk assessment
Humans
Influence
Kidney diseases
Kidney Diseases - etiology
Kidney Diseases - genetics
Kidney Diseases - therapy
Mass Spectrometry
Medicine
Medicine & Public Health
Metabolites
Metals
Mutation
Nephrology
Organic chemicals
Pesticides
Plasma
Risk factors
Scientific imaging
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Beschreibung
Zusammenfassung:New exposome-based approaches permit omic-scale characterization of the non-genetic contributors to kidney disease. High-resolution mass spectrometry analysis of plasma and urine samples captures a wide range of exogenous and endogenous metabolites that can be used in combination with genetic risk factors to identify new biomarkers of exposure and therapeutic approaches.
ISSN:1759-5061
1759-507X
DOI:10.1038/s41581-020-0302-9