A Fast-Degradable Nano-dressing with Potent Antibacterial Effect

In this study, clove essential oil was used as a green antibacterial agent. Its nanoemulsion dosage form with particle size 217.7 ± 11.45 nm and PDI 0.66 ± 0.09 was first prepared. By adding carbomer 940, nanoemulsion was then transformed into the nanogel (NGel) to improve the essential oil’s activi...

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Veröffentlicht in:BioNanoScience 2020-12, Vol.10 (4), p.983-990
Hauptverfasser: Zarenezhad, Elham, Abdollahi, Abbas, Esmaeili, Fariba, Satvati, Saha, Osanloo, Mahmoud
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creator Zarenezhad, Elham
Abdollahi, Abbas
Esmaeili, Fariba
Satvati, Saha
Osanloo, Mahmoud
description In this study, clove essential oil was used as a green antibacterial agent. Its nanoemulsion dosage form with particle size 217.7 ± 11.45 nm and PDI 0.66 ± 0.09 was first prepared. By adding carbomer 940, nanoemulsion was then transformed into the nanogel (NGel) to improve the essential oil’s activity and stability. Electrospun nanofibers of polyvinyl alcohol (PVANFs) with a mean diameter of 216 ± 14 nm were then prepared. The required characterizations such as ATR-FTIR spectroscopy, SEM image, and water contact angle were carried out. To easy usage topically, the NGel was impregnated on the PVANFs mat (NGelNFs). Interestingly, the prepared fast-degradable NGelNFs could inhibit (100%) the growth of four important pathogens, including Staphylococcus aureus , Escherichia coli , Pseudomonas aeruginosa , and Klebsiella pneumonia . Besides, the dressing was degraded after minutes of usage. The prepared GelNFs could be used as a capable and fast-degradable antibacterial substrate.
doi_str_mv 10.1007/s12668-020-00790-6
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subjects Antibacterial activity
Antiinfectives and antibacterials
Biological and Medical Physics
Biomaterials
Biophysics
Circuits and Systems
Contact angle
Degradation
E coli
Emulsions
Engineering
Essential oils
Klebsiella
Nanoemulsions
Nanofibers
Nanotechnology
Oils & fats
Polyvinyl alcohol
Pseudomonas aeruginosa
Substrates
title A Fast-Degradable Nano-dressing with Potent Antibacterial Effect
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