A Fast-Degradable Nano-dressing with Potent Antibacterial Effect

In this study, clove essential oil was used as a green antibacterial agent. Its nanoemulsion dosage form with particle size 217.7 ± 11.45 nm and PDI 0.66 ± 0.09 was first prepared. By adding carbomer 940, nanoemulsion was then transformed into the nanogel (NGel) to improve the essential oil’s activity and stability. Electrospun nanofibers of polyvinyl alcohol (PVANFs) with a mean diameter of 216 ± 14 nm were then prepared. The required characterizations such as ATR-FTIR spectroscopy, SEM image, and water contact angle were carried out. To easy usage topically, the NGel was impregnated on the PVANFs mat (NGelNFs). Interestingly, the prepared fast-degradable NGelNFs could inhibit (100%) the growth of four important pathogens, including Staphylococcus aureus , Escherichia coli , Pseudomonas aeruginosa , and Klebsiella pneumonia . Besides, the dressing was degraded after minutes of usage. The prepared GelNFs could be used as a capable and fast-degradable antibacterial substrate.