Prognostic impact of K-RAS mutational status and primary tumor location in patients undergoing resection for colorectal cancer liver metastases: an update

To determine the impact of KRAS mutation status on survival in patients undergoing surgery for colorectal liver metastases (CLM). Patients with resected CLM and KRAS mutations. Survival was compared between mt-KRAS and wt-KRAS. Of 662 patients, 174 (26.3%) were mt-KRAS and 488 (73.7%) wt-KRAS. mt-KR...

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Veröffentlicht in:	Future oncology (London, England) England), 2019-09, Vol.15 (27), p.3149-3157
Hauptverfasser:	O Connor, Juan M, Sanchez Loria, Fernando, Ardiles, Victoria, Grondona, Jorge, Sanchez, Pablo, Andriani, Oscar, Fauda, Martin, Brancato, Fernando, Huertas, Eduardo, Alvarez, Fernando, de Santibañes, Eduardo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Argentinian group Biological products Biomarkers, Tumor Cancer therapies Chemotherapy Colorectal cancer Colorectal Neoplasms - genetics Colorectal Neoplasms - mortality Colorectal Neoplasms - pathology Combined Modality Therapy Female Humans KRAS • liver metastases Liver Liver Neoplasms - mortality Liver Neoplasms - secondary Liver Neoplasms - surgery liver resection Male Metastasis Middle Aged molecular profiling multidisciplinary Mutation Neoplasm Staging Patients perioperative chemotherapy Prognosis Proto-Oncogene Proteins p21(ras) - genetics reference centres Surgery Survival Analysis Variables
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