Differential network analysis depicts regulatory mechanisms for hepatocellular carcinoma from diverse backgrounds

To elucidate the integrative combinational gene regulatory network landscape of hepatocellular carcinoma (HCC) molecular carcinogenesis from diverse background. Modified gene regulatory network analysis was used to prioritize differentially regulated genes and links. Integrative comparisons using bi...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Future oncology (London, England) England), 2019-12, Vol.15 (34), p.3917-3934
Hauptverfasser: Yu, Min-Cheng, Liu, Ji-Xiang, Ma, Xiao-Lu, Hu, Bo, Fu, Pei-Yao, Sun, Hai-Xiang, Tang, Wei-Guo, Yang, Zhang-Fu, Qiu, Shuang-Jian, Zhou, Jian, Fan, Jia, Xu, Yang
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:To elucidate the integrative combinational gene regulatory network landscape of hepatocellular carcinoma (HCC) molecular carcinogenesis from diverse background. Modified gene regulatory network analysis was used to prioritize differentially regulated genes and links. Integrative comparisons using bioinformatics methods were applied to identify potential critical molecules and pathways in HCC with different backgrounds. E2F1 with its surrounding regulatory links were identified to play different key roles in the HCC risk factor dysregulation mechanisms. Hsa-mir-19a was identified as showed different effects in the three HCC differential regulation networks, and showed vital regulatory role in HBV-related HCC. We describe in detail the regulatory networks involved in HCC with different backgrounds. E2F1 may serve as a universal target for HCC treatment.
ISSN:1479-6694
1744-8301
DOI:10.2217/fon-2019-0275