Just dose it

Just dose it

A dose threshold of one trillion nanoparticles in mice has been discovered and is shown to be crucial for overwhelming the nanoparticle uptake kinetics of liver Kupffer cells and for ensuring efficient nanoparticle delivery into solid tumours upon intravenous administration.

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Bibliographische Detailangaben
Veröffentlicht in:Nature materials 2020-12, Vol.19 (12), p.1257-1258
1. Verfasser: Lammers, Twan
Format: Artikel
Sprache:eng
Schlagworte:
631/67/1059/602
631/67/70
639/301/357/354
Biomaterials
Chemistry and Materials Science
Condensed Matter Physics
Humans
Intravenous administration
Materials Science
Nanoparticles
Nanotechnology
Neoplasms
News & Views
news-and-views
Optical and Electronic Materials
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Beschreibung
Zusammenfassung:A dose threshold of one trillion nanoparticles in mice has been discovered and is shown to be crucial for overwhelming the nanoparticle uptake kinetics of liver Kupffer cells and for ensuring efficient nanoparticle delivery into solid tumours upon intravenous administration.
ISSN:1476-1122
1476-4660
DOI:10.1038/s41563-020-00855-7