Highly oxygenated angucycline from Streptomyces sp. KCB15JA014
LC/MS-based chemical screening of culture extract led to a new highly oxygenated angucycline derivative, grecocycline D ( 1 ), from Streptomyces sp. KCB15JA014, isolated from a soil sample of Oedolgae in Jeju Island, Korea. The planar structure was determined on the basis of spectroscopic analysis,...
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| Veröffentlicht in: | Journal of antibiotics 2020-12, Vol.73 (12), p.859-862 |
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| container_title | Journal of antibiotics |
| container_volume | 73 |
| creator | Kim, Gil Soo Kim, Geum Jin Lee, Byeongsan Oh, Tae Hoon Kwon, Mincheol Lee, Jung-Sook Jang, Jun-Pil Choi, Hyukjae Ko, Sung-Kyun Hong, Young-Soo Jang, Jae-Hyuk Ahn, Jong Seog |
| description | LC/MS-based chemical screening of culture extract led to a new highly oxygenated angucycline derivative, grecocycline D (
1
), from
Streptomyces
sp. KCB15JA014, isolated from a soil sample of Oedolgae in Jeju Island, Korea. The planar structure was determined on the basis of spectroscopic analysis, including 1D and 2D NMR techniques as well as HRESIMS and comparison with data from the literature. A relative and absolute configuration of
1
was assigned by ROESY experiment and electronic circular dichroism calculation. Compound
1
showed weak inhibitory activity against indoleamine 2,3-dioxygenase. |
| doi_str_mv | 10.1038/s41429-020-0348-8 |
| format | Article |
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1
), from
Streptomyces
sp. KCB15JA014, isolated from a soil sample of Oedolgae in Jeju Island, Korea. The planar structure was determined on the basis of spectroscopic analysis, including 1D and 2D NMR techniques as well as HRESIMS and comparison with data from the literature. A relative and absolute configuration of
1
was assigned by ROESY experiment and electronic circular dichroism calculation. Compound
1
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1
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Streptomyces
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1
was assigned by ROESY experiment and electronic circular dichroism calculation. Compound
1
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KCB15JA014</atitle><jtitle>Journal of antibiotics</jtitle><stitle>J Antibiot</stitle><addtitle>J Antibiot (Tokyo)</addtitle><date>2020-12-01</date><risdate>2020</risdate><volume>73</volume><issue>12</issue><spage>859</spage><epage>862</epage><pages>859-862</pages><issn>0021-8820</issn><eissn>1881-1469</eissn><abstract>LC/MS-based chemical screening of culture extract led to a new highly oxygenated angucycline derivative, grecocycline D (
1
), from
Streptomyces
sp. KCB15JA014, isolated from a soil sample of Oedolgae in Jeju Island, Korea. The planar structure was determined on the basis of spectroscopic analysis, including 1D and 2D NMR techniques as well as HRESIMS and comparison with data from the literature. A relative and absolute configuration of
1
was assigned by ROESY experiment and electronic circular dichroism calculation. Compound
1
showed weak inhibitory activity against indoleamine 2,3-dioxygenase.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>32647213</pmid><doi>10.1038/s41429-020-0348-8</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0002-4363-4252</orcidid><orcidid>https://orcid.org/0000-0002-8202-1205</orcidid><orcidid>https://orcid.org/0000-0001-5166-4358</orcidid><orcidid>https://orcid.org/0000-0001-7768-2239</orcidid></addata></record> |
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| ispartof | Journal of antibiotics, 2020-12, Vol.73 (12), p.859-862 |
| issn | 0021-8820 1881-1469 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | 101/58 631/154/309/2144 631/92/349 Animals Anthraquinones - chemistry Anthraquinones - isolation & purification Anthraquinones - pharmacology Bacteriology Biomedical and Life Sciences Bioorganic Chemistry Brief Communication Cell Line - drug effects Circular Dichroism Cytotoxins - chemistry Cytotoxins - isolation & purification Cytotoxins - pharmacology Gas Chromatography-Mass Spectrometry Life Sciences Magnetic Resonance Spectroscopy Medicinal Chemistry Mice Microbiology Molecular Structure Organic Chemistry PC12 Cells - drug effects Rats Streptomyces - chemistry |
| title | Highly oxygenated angucycline from Streptomyces sp. KCB15JA014 |
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