Highly oxygenated angucycline from Streptomyces sp. KCB15JA014

LC/MS-based chemical screening of culture extract led to a new highly oxygenated angucycline derivative, grecocycline D ( 1 ), from Streptomyces sp. KCB15JA014, isolated from a soil sample of Oedolgae in Jeju Island, Korea. The planar structure was determined on the basis of spectroscopic analysis,...

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Veröffentlicht in:	Journal of antibiotics 2020-12, Vol.73 (12), p.859-862
Hauptverfasser:	Kim, Gil Soo, Kim, Geum Jin, Lee, Byeongsan, Oh, Tae Hoon, Kwon, Mincheol, Lee, Jung-Sook, Jang, Jun-Pil, Choi, Hyukjae, Ko, Sung-Kyun, Hong, Young-Soo, Jang, Jae-Hyuk, Ahn, Jong Seog
Format:	Artikel
Sprache:	eng
Schlagworte:	101/58 631/154/309/2144 631/92/349 Animals Anthraquinones - chemistry Anthraquinones - isolation & purification Anthraquinones - pharmacology Bacteriology Biomedical and Life Sciences Bioorganic Chemistry Brief Communication Cell Line - drug effects Circular Dichroism Cytotoxins - chemistry Cytotoxins - isolation & purification Cytotoxins - pharmacology Gas Chromatography-Mass Spectrometry Life Sciences Magnetic Resonance Spectroscopy Medicinal Chemistry Mice Microbiology Molecular Structure Organic Chemistry PC12 Cells - drug effects Rats Streptomyces - chemistry
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Zusammenfassung:	LC/MS-based chemical screening of culture extract led to a new highly oxygenated angucycline derivative, grecocycline D ( 1 ), from Streptomyces sp. KCB15JA014, isolated from a soil sample of Oedolgae in Jeju Island, Korea. The planar structure was determined on the basis of spectroscopic analysis, including 1D and 2D NMR techniques as well as HRESIMS and comparison with data from the literature. A relative and absolute configuration of 1 was assigned by ROESY experiment and electronic circular dichroism calculation. Compound 1 showed weak inhibitory activity against indoleamine 2,3-dioxygenase.
ISSN:	0021-8820 1881-1469
DOI:	10.1038/s41429-020-0348-8