A practical strategy to access chiral α-aryloxy carboxylic acids through ion-pairing directed asymmetric hydrogenation

A practical strategy to access chiral α-aryloxy carboxylic acids through ion-pairing directed asymmetric hydrogenation

A series of optically active α-aryloxy carboxylic acids were obtained via Chenphos/Rh catalyzed highly efficient asymmetric hydrogenation. The proposed ion-pairing interaction between the ligand and the substrate plays a vital role in achieving high enantioselectivity.

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Veröffentlicht in:Organic Chemistry Frontiers 2020-12, Vol.7 (24), p.4069-4073
Hauptverfasser: Yao, Lin, Ma, Haixia, Nie, Zhuang, Nie, Huifang, Zhang, Dongxu, Wei, Zhao, Shen, Zhanhong, Chen, Weiping, Jiang, Ru, Zhang, Shengyong
Format: Artikel
Sprache:eng
Schlagworte:
Asymmetry
Carboxylic acids
Crystallography
Enantiomers
Hydrogenation
Optical activity
Organic chemistry
Substrates
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Zusammenfassung:A series of optically active α-aryloxy carboxylic acids were obtained via Chenphos/Rh catalyzed highly efficient asymmetric hydrogenation. The proposed ion-pairing interaction between the ligand and the substrate plays a vital role in achieving high enantioselectivity.
ISSN:2052-4129
2052-4110
2052-4129
2052-4110
DOI:10.1039/D0QO01205J