Amidation Reaction of Quinoline‐3‐carboxylic Acids with Tetraalkylthiuram Disulfides under Simple Conditions: A facile Synthesis of Quinoline‐3‐carboxamides

A highly efficient and simple procedure for the synthesis quinoline‐3‐carboxamides and their analogues via amidation reaction of quinoline‐3‐carboxylic acids with tetraalkylthiuram disulfides has been developed. The reaction proceeds efficiently under simple reaction conditions and features the generality of broad scope of substrates with good yields. This protocol provides a convenient procedure for the synthesis of various aza‐heteroaromatic carboxamides, which is of pharmaceutical interest. A facile and convenient protocol for the synthesis of quinoline‐3‐carboxamides their analogues using tetraalkylthiuram disulfides as the amine sources under metal and additive free conditions has been achieved. This method allows the efficient coupling of diverse quinoline‐3‐carboxylic acids with tetraalkylthiuram disulfides through a simply mixing operation.