Levosimendan with other inotropes or vasopressors: Should you combine them?

•In our AHF unit, levosimendan was often combined with other inotropes/vasopressors.•Such combination (LVc) was well-tolerated compared to isolated levosimendan (LVi).•No differences in adverse events nor intra-hospital death were found between groups.•The safety and effectiveness of combination tre...

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Veröffentlicht in:	The American journal of emergency medicine 2020-12, Vol.38 (12), p.2723-2726
Hauptverfasser:	Cunha, Gonçalo J.L., Rocha, Bruno M.L., Gomes, Rita V., Ferraz, Mário, Fernandes, Lúcia, Morais, Rui, Campos, Luís, Araújo, Inês, Fonseca, Cândida
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Aged Aged, 80 and over Arterial Pressure Blood pressure Cardiac arrhythmia Cardiotonic Agents - therapeutic use Cardiovascular disease Coronary artery Demographics Demography Diabetes mellitus Dobutamine - therapeutic use Dopamine Dopamine - therapeutic use Drug Therapy, Combination Ejection fraction Emergency medical care Epidermal growth factor receptors Etiology Female Fibrillation Glomerular filtration rate Heart diseases Heart failure Heart Failure - drug therapy Heart Failure - physiopathology Heart Rate Hemodynamics Hospital Mortality Hospitalization Humans Hypotension Hypotension - chemically induced Investigations Ischemia Laboratories Length of Stay Magnesium Male Medical prognosis Middle Aged Norepinephrine Norepinephrine - therapeutic use Peptides Potassium Simendan - therapeutic use Tachycardia, Supraventricular - chemically induced Treatment Outcome Vasoconstrictor Agents - therapeutic use Weaning
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Beschreibung
Zusammenfassung:	•In our AHF unit, levosimendan was often combined with other inotropes/vasopressors.•Such combination (LVc) was well-tolerated compared to isolated levosimendan (LVi).•No differences in adverse events nor intra-hospital death were found between groups.•The safety and effectiveness of combination treatment is worth being further assessed.
ISSN:	0735-6757 1532-8171
DOI:	10.1016/j.ajem.2020.03.059