Antimicrobial activity of new transition metal complexes of sulfamethoxazole on nhibiter by Staphylococcus aureus, Pseudomonas aeruginosa, Salmonella typhi and Escherichia coli

The study aimed to evaluate the ability of Sulfamethoxazole inhibition growth of Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, and Salmonella typhi. In an alcoholic medium, Sulfamethoxazole treated with Gold (Au), Palladium (Pd), and Rhodium (Rh) ions to make a new complex that was characterized via flame atomic absorption, UV-Vis spectroscopy and other methods. Both of Sulfamethoxazole and the complex studied to inhibiter growth of bacteria with different concentrations (125, 250, 500, and 1000) mg/l, respectively, incubating 24hr / 37°C. The result showed that increasing efficiency of SMX when ligand with concentration (125, 250, 500, 1000) mg/ml of (Au), via inhibiting (Staph. aureus and Ps. aeruginosa), with (0, 5, 5, 14) mm, (10, 16, 19,21) mm, and (Rh) was inhibited (Staph. aureus, Ps. aeruginosa, and Salm. typhi) with (15, 16, 18, and 22)mm, (12, 14, 16, and 18)mm, and (15, 16, 17, and 21)mm, respectively, also observe increasing the efficiency of SMX when ligand with concentration (125, 250, 500, and 1000)mg/ml of (Pd), which effect on the growth of Ps. aeruginosa after incubating with inhibition zone (13, 14, 15, 18)mm, that all compared with the value of inhibiting bacterial isolates by using SMX as a control.