The preliminary study on expression and clinical value of Platelet-derived growth factor BB, Hypoxia inducible factor-1α and C-C motif chemokine receptor-2 in the peripheral blood during the pathogenesis of Graves disease

Backgroud: Platelet-derived growth factor BB (PDGF-BB) plays an important role in the development of GD(Graves' disease). However, it is still unknown whether PDGF-BB is expressed in peripheral blood and whether the expression of PDGF-BB contributes to GD. We aim to study the expression of PDGF-BB, Hypoxia inducible factor(HIF)-1α and C-C motif chemokine receptor(CCR)-2 in peripheral blood of patients with GD and explore its effect and potential mechanism in pathogenesis. 41 patients with GD (GD group) and 45 healthy people(control group) were chosen. The concentration of PDGF-BB and HIF-1α in peripheral blood specimens were detected and compared between the two groups. The expression of CCR2 in macrophages in the peripheral blood specimens were examined using FCM (Flow Cytometry). Both of PDGF-BB and HIF-1α were expressed in human peripheral blood from two groups. Compared with specimens from healthy people, there were statistically increasing concentration of PDGF-BB and HIF-1α in GD group (P