Learning and memory enhancing properties of coenzyme Q10 in amnestic albino Wistar rats

Results: Co-Q10 at higher doses (400 mg/kg) showed significant activity in EPM, pole climbing test, and NOR test for assessing the learning and memory skills when compared to the control group. Conclusion: The present study results revealed that Co-Q10 high doses potentiated the process of learning and memory skills when tested using EPM, pole climbing test, and NOR test which are considered as standard paradigms of learning and memory screening models. [4] The pathophysiology of Alzheimer's dementia involves microglial activation, excessive release of pro-inflammatory cytokines, formation of neurofibrillary tangles due to accumulation of Tau which is a microtubule associated protein, also disrupted mitochondrial function accompanied by overproduction of ROS, and oxidized molecules. The current therapy for Alzheimer's includes cholinesterase inhibitors, antiglutamatergic, atypical antipsychotics, and anti-amyloid therapy which remains still unfavorable in slowing down completely the AD progression and also has many untoward effects. [...]new treatment strategies are still necessary to improve AD patient care.