Microfluidics: IFlowPlate—A Customized 384‐Well Plate for the Culture of Perfusable Vascularized Colon Organoids (Adv. Mater. 46/2020)

Microfluidics: IFlowPlate—A Customized 384‐Well Plate for the Culture of Perfusable Vascularized Colon Organoids (Adv. Mater. 46/2020)

Human stem‐cell‐derived organoids have provided new opportunities to model biological processes and recapitulate organ development. However, organoid systems lack perfusable vascular networks to deliver nutrients and drugs. In article number 2002974, Boyang Zhang and co‐workers introduce IFlowPlate—...

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Veröffentlicht in:Advanced materials (Weinheim) 2020-11, Vol.32 (46), p.n/a
Hauptverfasser: Rajasekar, Shravanthi, Lin, Dawn S. Y., Abdul, Lyan, Liu, Amy, Sotra, Alexander, Zhang, Feng, Zhang, Boyang
Format: Artikel
Sprache:eng
Schlagworte:
Biological activity
Colon
Drug delivery systems
hydrogels
Materials science
Microfluidics
Nutrients
organoids
organ‐on‐a‐chip
vasculature
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Zusammenfassung:Human stem‐cell‐derived organoids have provided new opportunities to model biological processes and recapitulate organ development. However, organoid systems lack perfusable vascular networks to deliver nutrients and drugs. In article number 2002974, Boyang Zhang and co‐workers introduce IFlowPlate—a microfluidic system with an “open‐well” design in a 384‐well plate format that can be used to vascularize and intravascularly perfuse organoids. This image shows three independently perfused microvascular networks in an IFlowPlate.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.202070345