Immunometabolism in Caenorhabditis elegans

[...]the metabolic pathways that regulate nutrient acquisition, energy storage, and resource allocation in host cells must adapt to pathogen stress in order to meet the physiological demands of the host during infection. Insulin/insulin-like growth factor signaling is strongly conserved across metazoan evolution. [...]examination of the mechanisms by which the DAF-2/DAF-16 pathway integrates information about host nutrition to control metabolism, pathogen resistance, and life span may yield fundamental insights about immunometabolism. [...]a core host defense pathway in C. elegans, the p38 MAP PMK-1 pathway, is activated by nutrient signals independently of canonical mechanisms that sense food availability and accelerates aging when it is aberrantly induced, providing an example of the deleterious effects of immune activation on longevity [13]. [...]nematodes with loss-of-function mutations in fat-6 and fat-7 are hypersusceptible to infection by diverse pathogens, which can be rescued by the addition of exogenous oleate [15].