Electrochemical Determination of the Steroid Tibolone and Its Metabolites in Saliva Samples

Electrochemical Determination of the Steroid Tibolone and Its Metabolites in Saliva Samples

Tibolone (TIB) is a synthetic steroid banned by the World Anti‐Doping Agency (WADA) due to its similar properties to estrogen and progesterone. In this work, a simple and low‐cost electrochemical method for the determination of TIB and its metabolites (3‐α hydroxytibolone and 3‐β hydroxytibolone) in...

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Veröffentlicht in:ChemElectroChem 2020-11, Vol.7 (21), p.4469-4476
Hauptverfasser: Silva, Weberson P., Rocha, Raquel G., Felisbino, John K. R. P., Sousa, Raquel M. F., Munoz, Rodrigo A. A., Richter, Eduardo M.
Format: Artikel
Sprache:eng
Schlagworte:
Boron
boron-doped diamond
Diamonds
electrochemical mechanisms
Electrodes
Electrolytes
Estrogens
forensic chemistry
Metabolites
rapid analysis
Saliva
Statistical analysis
Statistical methods
Steroids
synthetic steroids
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Zusammenfassung:Tibolone (TIB) is a synthetic steroid banned by the World Anti‐Doping Agency (WADA) due to its similar properties to estrogen and progesterone. In this work, a simple and low‐cost electrochemical method for the determination of TIB and its metabolites (3‐α hydroxytibolone and 3‐β hydroxytibolone) in authentic human saliva is reported. Square‐wave voltammetry (SWV) with an unmodified boron‐doped diamond (BDD) electrode and phosphate buffer 0.1 mol L−1 were selected as the electrochemical technique, working electrode, and supporting electrolyte, respectively. Analytical characteristics of the proposed method include good repeatability (RSD
ISSN:2196-0216
2196-0216
DOI:10.1002/celc.202001248