A Randomized Trial Comparing Antibiotics with Appendectomy for Appendicitis

In a randomized trial comparing antibiotic therapy with appendectomy in patients with appendicitis, antibiotics were noninferior on the basis of EQ-5D scores. In the antibiotics group, nearly 3 in 10 participants had undergone appendectomy by 90 days, and complications were more common, especially i...

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Veröffentlicht in:	The New England journal of medicine 2020-11, Vol.383 (20), p.1907-1919
Hauptverfasser:	Flum, David R, Davidson, Giana H, Monsell, Sarah E, Shapiro, Nathan I, Odom, Stephen R, Sanchez, Sabrina E, Drake, F Thurston, Fischkoff, Katherine, Johnson, Jeffrey, Patton, Joe H, Evans, Heather, Cuschieri, Joseph, Sabbatini, Amber K, Faine, Brett A, Skeete, Dionne A, Liang, Mike K, Sohn, Vance, McGrane, Karen, Kutcher, Matthew E, Chung, Bruce, Carter, Damien W, Ayoung-Chee, Patricia, Chiang, William, Rushing, Amy, Steinberg, Steven, Foster, Careen S, Schaetzel, Shaina M, Price, Thea P, Mandell, Katherine A, Ferrigno, Lisa, Salzberg, Matthew, DeUgarte, Daniel A, Kaji, Amy H, Moran, Gregory J, Saltzman, Darin, Alam, Hasan B, Park, Pauline K, Kao, Lillian S, Thompson, Callie M, Self, Wesley H, Yu, Julianna T, Wiebusch, Abigail, Winchell, Robert J, Clark, Sunday, Krishnadasan, Anusha, Fannon, Erin, Lavallee, Danielle C, Comstock, Bryan A, Bizzell, Bonnie, Heagerty, Patrick J, Kessler, Larry G, Talan, David A
Format:	Artikel
Sprache:	eng
Schlagworte:	Absenteeism Administration, Intravenous Adult Anti-Bacterial Agents - adverse effects Anti-Bacterial Agents - therapeutic use Antibiotics Appendectomy Appendectomy - statistics & numerical data Appendicitis Appendicitis - complications Appendicitis - drug therapy Appendicitis - surgery Appendix Appendix - pathology Appendix - surgery Coronaviruses COVID-19 Fecal Impaction Female Health Status Hospitalization - statistics & numerical data Humans Infections Laparoscopy Male Middle Aged Ostomy Pain Patient-centered care Patients Peritonitis Postoperative Complications - epidemiology Quality of Life Regression analysis Sepsis Statistical analysis Surgery Surveys and Questionnaires Treatment Outcome Tumors
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Beschreibung
Zusammenfassung:	In a randomized trial comparing antibiotic therapy with appendectomy in patients with appendicitis, antibiotics were noninferior on the basis of EQ-5D scores. In the antibiotics group, nearly 3 in 10 participants had undergone appendectomy by 90 days, and complications were more common, especially in those with an appendicolith.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa2014320