Cross‐species transmission and evolutionary dynamics of canine distemper virus during a spillover in African lions of Serengeti National Park

The outcome of pathogen spillover from a reservoir to a novel host population can range from a “dead‐end” when there is no onward transmission in the recipient population, to epidemic spread and even establishment in new hosts. Understanding the evolutionary epidemiology of spillover events leading...

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Veröffentlicht in:Molecular ecology 2020-11, Vol.29 (22), p.4308-4321
Hauptverfasser: Weckworth, Julie K., Davis, Brian W., Dubovi, Edward, Fountain‐Jones, Nicholas, Packer, Craig, Cleaveland, Sarah, Craft, Meggan E., Eblate, Ernest, Schwartz, Michael, Mills, L. Scott, Roelke‐Parker, Melody
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Sprache:eng
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Zusammenfassung:The outcome of pathogen spillover from a reservoir to a novel host population can range from a “dead‐end” when there is no onward transmission in the recipient population, to epidemic spread and even establishment in new hosts. Understanding the evolutionary epidemiology of spillover events leading to discrete outcomes in novel hosts is key to predicting risk and can lead to a better understanding of the mechanisms of emergence. Here we use a Bayesian phylodynamic approach to examine cross‐species transmission and evolutionary dynamics during a canine distemper virus (CDV) spillover event causing clinical disease and population decline in an African lion population (Panthera leo) in the Serengeti Ecological Region between 1993 and 1994. Using 21 near‐complete viral genomes from four species we found that this large‐scale outbreak was likely  ignited by a single cross‐species spillover event from a canid reservoir to noncanid hosts
ISSN:0962-1083
1365-294X
DOI:10.1111/mec.15449