The relation between Helicobacter pylori immunoglobulin G seropositivity and leukocyte telomere length in US adults from NHANES 1999‐2000

The relation between Helicobacter pylori immunoglobulin G seropositivity and leukocyte telomere length in US adults from NHANES 1999‐2000

Background Helicobacter pylori (H pylori) immunoglobulin G (IgG) seropositivity is prevalent but its relation with leukocyte telomere length (LTL), a cellular aging biomarker, is unclear. Methods Among 3,472 participants from the National Health and Nutrition Examination Survey (NHANES) cycle 1999‐2...

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Veröffentlicht in:Helicobacter (Cambridge, Mass.) Mass.), 2020-12, Vol.25 (6), p.n/a
Hauptverfasser: Huang, Jin‐Wen, Xie, Chuanbo, Niu, Zhongzheng, He, Long‐Jun, Li, Jian‐Jun
Format: Artikel
Sprache:eng
Schlagworte:
Aging
Biomarkers
Geriatrics
Helicobacter pylori
H pylori
IgG
IgG antibody
Immune status
Immunoassays
Immunoglobulin G
Immunoglobulins
Leukocytes
NHANES
Nutrition
Older people
Polymerase chain reaction
Population
Population distribution
Regression analysis
Regression models
telomere length
Telomeres
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Zusammenfassung:Background Helicobacter pylori (H pylori) immunoglobulin G (IgG) seropositivity is prevalent but its relation with leukocyte telomere length (LTL), a cellular aging biomarker, is unclear. Methods Among 3,472 participants from the National Health and Nutrition Examination Survey (NHANES) cycle 1999‐2000, LTL was measured with the quantitative polymerase chain reaction. H pylori IgG was measured by enzyme‐linked immunosorbent assays and defined as seropositivity with an immune status ratio score > 0.9. We used linear regression models to examine the relation of H pylori IgG seropositivity with continuous LTL and logistic regression for the relation with short LTL (
ISSN:1083-4389
1523-5378
DOI:10.1111/hel.12760