Osimertinib in Resected EGFR-Mutated Non–Small-Cell Lung Cancer

The incidence of recurrence after curative resection among patients with stage IB, II, or IIIA non–small-cell lung cancer is high and is only slightly lower with adjuvant chemotherapy. A randomized trial of adjuvant osimertinib involving patients with EGFR mutation–positive NSCLC showed a substantia...

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Veröffentlicht in:	The New England journal of medicine 2020-10, Vol.383 (18), p.1711-1723
Hauptverfasser:	Wu, Yi-Long, Tsuboi, Masahiro, He, Jie, John, Thomas, Grohe, Christian, Majem, Margarita, Goldman, Jonathan W, Laktionov, Konstantin, Kim, Sang-We, Kato, Terufumi, Vu, Huu-Vinh, Lu, Shun, Lee, Kye-Young, Akewanlop, Charuwan, Yu, Chong-Jen, de Marinis, Filippo, Bonanno, Laura, Domine, Manuel, Shepherd, Frances A, Zeng, Lingmin, Hodge, Rachel, Atasoy, Ajlan, Rukazenkov, Yuri, Herbst, Roy S
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylamides - adverse effects Acrylamides - therapeutic use Adult Aged Aged, 80 and over Aniline Compounds - adverse effects Aniline Compounds - therapeutic use Antineoplastic Agents - adverse effects Antineoplastic Agents - therapeutic use Cancer therapies Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - mortality Carcinoma, Non-Small-Cell Lung - surgery Central nervous system Central nervous system diseases Chemotherapy Chemotherapy, Adjuvant Committees Death Disease-Free Survival Double-Blind Method Epidermal growth factor Epidermal growth factor receptors ErbB Receptors - genetics Female Humans Lung cancer Lung Neoplasms - drug therapy Lung Neoplasms - genetics Lung Neoplasms - mortality Lung Neoplasms - surgery Lymphatic Metastasis Male Middle Aged Mutation Neoplasm Recurrence, Local Neoplasm Staging Non-small cell lung carcinoma Patients Pneumonectomy Protein Kinase Inhibitors - adverse effects Protein Kinase Inhibitors - therapeutic use Safety Small cell lung carcinoma Statistical analysis Targeted cancer therapy
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Zusammenfassung:	The incidence of recurrence after curative resection among patients with stage IB, II, or IIIA non–small-cell lung cancer is high and is only slightly lower with adjuvant chemotherapy. A randomized trial of adjuvant osimertinib involving patients with EGFR mutation–positive NSCLC showed a substantial decrease in recurrence. Central nervous system relapses were also significantly reduced.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa2027071