Cochrane for Clinicians: Extended-Release Bupropion for Preventing Seasonal Affective Disorder in Adults

Evidence-Based Answer When started in the fall, extended-release bupropion, 300 mg once daily, is effective in preventing recurrent symptoms in high-risk adults with a history of SAD (number needed to treat [NNT] = 5), as well as those at lower risk (NNT = 8). Headaches, nausea, and insomnia may limit adherence to treatment.1 (Strength of Recommendation: B, based on inconsistent or limited-quality patient-oriented evidence.) Practice Pointers SAD is a recurrent depressive disorder that occurs only during a particular season, typically the winter months.2 SAD is more common at northern latitudes; the prevalence is estimated at 9% in the northern United States,3 and two-thirds of patients experience the symptoms every year.4 Preventive measures are of particular interest for this group of patients. [...]generation antidepressants for preventing seasonal affective disorder in adults.