Hepatoprotective activity of Etlingera elatior (Jack) R.M. Smith extract against ccl4 -induced hepatic toxicity in male wistar rats

The cell-protecting of extract was performed to Wistar male rats to measure their total bilirubin, direct bilirubin, indirect bilirubin, SGOT, SGPT, and ALP levels post-treated with Wualae fruit extract at dose 200, 300, and 400 mg/kgBw for 7 d, and induced with CCl4 the next day. [...]Wualae fruit extract has protective effect toward CCl4induced hepatotoxicity at dose 200 and 300mg/kgBw and able to decreases bilirubin, SGOT, SGPT, and ALP levels. Previous studies showed that Wualae has activity as hepatoprotective(7). [...]our study aims to investigate Wualae fruit extract in decreasing total bilirubin, direct bilirubin, indirect bilirubin, SGOT, SGPT, and ALT level and cellprotecting in carbon tetrachloride (CCl4)-induced rats. Materials: Material used in this study were Wualae Fruit (Etlingera elatior (Jack) R.M. Smith), Wistar male rats, 0.9% NaCl, Na CMC 0.5%, formalin 10%, ether, ethanol 96%, xylol, paraffin, ethanol (70%, 80%, 90%, and 100%), hematoxylin solution, and eosin solution.