Design and evaluation of adhesive type transdermal patches of carvedilol

The investigation reveals that the adhesive type patches of carvedilol were stable and devoid of skin irritation and hypersensitive response. [...]may serve as a potential drug delivery system for carvedilol. The DIA patches has several merits over other patches due to its small size and thickness, better flexibility, uncomplicated production process, straightforward design and patient choice6-8. [...]dose adjustment, for example for patients with impaired hepatic or renal functions, can easily be attained by cutting/dividing the patch9. In case of DIA patch system, drug incorporated adhesive layer is in contact with the skin surface after application. [...]the selection of a suitable adhesive is important. The patches were kept for evaporation of residual solvent and laminated with polyster film laminate (Scotch Pak™ 1012) backing layer and cut into cut into suitable sizes (figure was made supplementary), packed into aluminium foil, and stored at room temperature until further study.