Synthesis and molecular docking studies of some new pyrazoline derivatives for antimicrobial properties

[...]docking plays an important in the rational drug design. Predicting the mode of protein ligand interaction can assume the active site of the protein molecule and further help in protein annotation. [...]molecular docking has major application in drug designing and discovery. Some of these compounds also possess anti-inflammatory, antidiabetics and analgesic properties. [...]pyrazolines have also been used extensively as useful synthons in organic synthesis. [...]with the borer 9-mm diameter were bored on the lawn culture and 100ul of the each test compounds were poured in to the wells and 24 h after incubation at 37°C, the inhibition zone was measured in mm. The plates were incubated for 24 h at 37°C. The inhibition zone that appeared after 24 h, around the well in each plate were measured as zone of inhibition in mm. Experiments were triplicates and standard deviation was calculated.