Larotrectinib-Enhanced Radioactive Iodine Uptake in Advanced Thyroid Cancer

Larotrectinib-Enhanced Radioactive Iodine Uptake in Advanced Thyroid Cancer

In a woman with thyroid cancer expressing an EML4-NTRK3 fusion gene, the cancer had become refractory to radioactive iodine when the capacity of the tumors to take up iodine was lost. The use of larotrectinib, an NTRK inhibitor, resulted in a partial response and restored iodine uptake in the tumor...

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Veröffentlicht in:The New England journal of medicine 2020-10, Vol.383 (17), p.1686-1687
Hauptverfasser: Groussin, Lionel, Clerc, Jérôme, Huillard, Olivier
Format: Artikel
Sprache:eng
Schlagworte:
Cancer therapies
Fusion protein
Iodine
Kinases
Mutation
Scintigraphy
Thyroid cancer
Tumor cells
Tumors
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Zusammenfassung:In a woman with thyroid cancer expressing an EML4-NTRK3 fusion gene, the cancer had become refractory to radioactive iodine when the capacity of the tumors to take up iodine was lost. The use of larotrectinib, an NTRK inhibitor, resulted in a partial response and restored iodine uptake in the tumor cells.
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJMc2023094