Vaccine Platforms: Biosynthesis of Self‐Assembled Proteinaceous Nanoparticles for Vaccination (Adv. Mater. 42/2020)

Vaccine Platforms: Biosynthesis of Self‐Assembled Proteinaceous Nanoparticles for Vaccination (Adv. Mater. 42/2020)

In article number 2002940, Li Zhu, Wei Wei, Guanghui Ma, Hengliang Wang, and co‐workers present a Nano‐B5 vaccine platform that is fully bio‐synthesized in bacteria. This self‐assembled platform serves as a versatile chassis to combine adjuvant modular and display peptide or polysaccharide antigens....

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Veröffentlicht in:Advanced materials (Weinheim) 2020-10, Vol.32 (42), p.n/a
Hauptverfasser: Pan, Chao, Wu, Jun, Qing, Shuang, Zhang, Xiao, Zhang, Lulu, Yue, Hua, Zeng, Ming, Wang, Bin, Yuan, Zheng, Qiu, Yefeng, Ye, Huahu, Wang, Dongshu, Liu, Xiankai, Sun, Peng, Liu, Bo, Feng, Erling, Gao, Xiaoyong, Zhu, Li, Wei, Wei, Ma, Guanghui, Wang, Hengliang
Format: Artikel
Sprache:eng
Schlagworte:
AB5 toxins
Antigens
Biosynthesis
Chassis
conjugate vaccines
Nanoparticles
nanovaccines
Polysaccharides
self‐assembled proteins
Vaccines
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Zusammenfassung:In article number 2002940, Li Zhu, Wei Wei, Guanghui Ma, Hengliang Wang, and co‐workers present a Nano‐B5 vaccine platform that is fully bio‐synthesized in bacteria. This self‐assembled platform serves as a versatile chassis to combine adjuvant modular and display peptide or polysaccharide antigens. Upon excellent lymph‐node targeting and immunoresponse elicitation in vivo, strong prophylactic effects and efficient therapeutic effects are achieved.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.202070313