The associations between phosphatidylethanolamine N-methyltransferase gene, dietary choline intake and anxiety and depression in healthy UK adults

In England, one in six adults met the criteria for a common mental disorder (CMD) such as anxiety or depression in 2014. [...]women were more likely to experience CMD symptoms than men(1). Choline intake was quantified using the United States Department of Agriculture food composition database considering it is not a part of the UK food composition tables. Within the abnormal anxiety group, the mean anxiety scores were higher in carriers of the rs4646343 risk allele compared to those homozygous for the G allele (GT+TT 13.8 ± 2.3 vs GG 11.5 ± 1.2, p = 0.018, Mann-Whitney U test).