Therapeutic Trials of Johne’s Disease With Amikacin and Cinnamon in Experimentally Challenged Rabbits

ABSTRACT Johne's disease has its economic importance worldwide because of heavy treatment cost and poor outcomes. This study is conducted on experimentally challenged rabbits to observe the efficacy of amikacin and cinnamon. A total of 40 SPF(specific pathogen free) rabbits were selected at the age of two months. Rabbits were given experimental challenge with oral inoculum of pure culture of MAP. These rabbits were divided into four groups; three test and one control group. Histopathological lesions were observed before and after the therapeutic trials and lesions scoring was given according to the standard. On the basis of the changes in histopathological lesions, the effect of these therapeutic agents was noted. Amikacin showed marked differences in terms of decrease in severity of lesions weather used alone or in combination with cinnamon in rabbits. It was observed that amikacin and cinnamon having synergistic effect in rabbits and are economically important drugs in treatment of Johne's disease.