Mitochondrial DNA copy number and cytogenetic damage among fuel filling station attendants

Mitochondrial DNA copy number and cytogenetic damage among fuel filling station attendants

Fuel filling attendants are constantly exposed to the complex mixture of gasoline and all refinery environments are probably carcinogenic for humans. These workers are considered as an unorganized group in India and unaware of the risk. The present study was focused to monitor workplace pollutants (...

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Veröffentlicht in:Environmental and molecular mutagenesis 2020-10, Vol.61 (8), p.820-829
Hauptverfasser: Gaikwad, Avinash S., Mahmood, Riaz, Beerappa, Ravichandran, Karunamoorthy, Panjakumar, Venugopal, Dhananjayan
Format: Artikel
Sprache:eng
Schlagworte:
8-Hydroxydeoxyguanosine
Benzene
Biomonitoring
Carbon monoxide
Carcinogens
Case-Control Studies
Chromosome Aberrations
Copy number
Cytogenetics
Deoxyguanosine
Deoxyribonucleic acid
DNA
DNA Copy Number Variations
DNA, Mitochondrial - genetics
Exposure
Female
Gasoline
Genotoxicity
Health hazards
Humans
Hydrocarbons
India
Male
Malignancy
Metabolites
Micronuclei
Mitochondrial DNA
Occupational Exposure
Organic compounds
Particulate emissions
Particulate matter
Personal protective equipment
Phenols
Pollutants
Protective equipment
Refineries
Service stations
unorganized group workers
VOCs
volatile organic compound
Volatile organic compounds
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Zusammenfassung:Fuel filling attendants are constantly exposed to the complex mixture of gasoline and all refinery environments are probably carcinogenic for humans. These workers are considered as an unorganized group in India and unaware of the risk. The present study was focused to monitor workplace pollutants (particulate matter size 10 [PM10 μm], total volatile organic compound [VOC], and carbon monoxide [CO]), benzene exposure (phenol), and to evaluate their genotoxicity effect with reference to relative mitochondrial DNA copy number (MtDNAcn), 8‐OHdG (8‐hydroxy‐2′‐deoxyguanosine), and micronuclei (MN) frequency (%) among fuel filling attendants. This study recorded 318 ± 134 and 1,050 ± 260 μg/m3 time‐weighted average concentration of PM10 and CO, respectively. However, total VOC levels recorded were below the detectable level (BDL) to 290 ± 50 μg/m3. A total of 53 subjects (26 exposed and 27 control) participated in this study with similar sociodemographic information. It was noticed that fuel filling attendants were not using proper personal protective equipment (PPE) and are younger generation. The significantly (p = 
ISSN:0893-6692
1098-2280
DOI:10.1002/em.22404