Formulation, characterization and in vitro anti-leishmanial evaluation of amphotericin B loaded solid lipid nanoparticles coated with vitamin B12-stearic acid conjugate

Despite the advancement of new anti-leishmanials, amphotericin B (AmB) prevails as one of the most potent agent in the treatment of visceral leishmaniasis (VL), a neglected tropical disease affecting mostly poverty ridden and underdeveloped regions of the globe. Nonetheless, many patients display in...

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Veröffentlicht in:	Materials Science & Engineering C 2020-12, Vol.117, p.111279, Article 111279
Hauptverfasser:	Singh, Aakriti, Yadagiri, Ganesh, Parvez, Shabi, Singh, Om Prakash, Verma, Anurag, Sundar, Shyam, Mudavath, Shyam Lal
Format:	Artikel
Sprache:	eng
Schlagworte:	Amastigotes Amphotericin B Bioavailability Conjugates Cyanocobalamin Drug delivery systems Encapsulation Evaporation Hydrogels Internalization Intolerance Lipids Materials science Nanoparticles Polydispersity Poverty Solid lipid nanoparticles Stearic acid Toxicity Tropical diseases Vector-borne diseases Visceral leishmaniasis Vitamin B12 Vitamin B12-stearic acid conjugate
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