Potential of environmental concentrations of the musks galaxolide and tonalide to induce oxidative stress and genotoxicity in the marine environment

Polycyclic musk compounds have been identified in environmental matrices (water, sediment and air) and in biological tissues in the last decade, yet only minimal attention has been paid to their chronic toxicity in the marine environment. In the present research, the clams Ruditapes philippinarum we...

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Veröffentlicht in:	Marine environmental research 2020-09, Vol.160, p.105019, Article 105019
Hauptverfasser:	Ehiguese, Friday O., Alam, Md Rushna, Pintado-Herrera, Marina G., Araújo, Cristiano V.M., Martin-Diaz, M. Laura
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute toxicity Biological stress Biomarkers Biotransformation Chronic toxicity Clams Contaminants of emerging concern Damage Deoxyribonucleic acid Digestive glands DNA DNA damage Environmental risk assessment Enzymatic activity Enzyme activity Fragrances Genotoxicity Marine environment Marine molluscs Marine organisms Musk Oxidative stress Tissue Tissues Tonalide Toxicity Xenobiotics
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Zusammenfassung:	Polycyclic musk compounds have been identified in environmental matrices (water, sediment and air) and in biological tissues in the last decade, yet only minimal attention has been paid to their chronic toxicity in the marine environment. In the present research, the clams Ruditapes philippinarum were exposed to 0.005, 0.05, 0.5, 5 and 50 μg/L of the fragrances Galaxolide® (HHCB) and Tonalide® (AHTN) for 21 days. A battery of biomarkers related with xenobiotics biotransformation (EROD and GST), oxidative stress (GPx, GR and LPO) and genotoxicity (DNA damage) were measured in digestive gland tissues. HHCB and AHTN significantly (p
ISSN:	0141-1136 1879-0291
DOI:	10.1016/j.marenvres.2020.105019