Evaluating and comparing the image quality and quantification accuracy of SiPM-PET/CT and PMT-PET/CT

Objective The aim of this study was to evaluate the image quality and the quantification accuracy of Biograph Vision PET/CT scanner as a SiPM-PET in comparison to the conventional PMT-PET, Biograph mCT PET/CT scanner. Methods This study consisted of a phantom study and a retrospective clinical analysis where patients underwent 18 F-FDG PET/CT in both PET systems. The body phantom of the NEMA IEC with 10–37 mm diameter spheres were filled with an 18 F-FDG solution. The root mean square error (RMSE) of SUV, the detectability of 10-mm sphere, NEC phantom , the background variability ( N 10mm ) and the contrast-noise-ratio ( Q H,10 mm / N 10mm ) were calculated based on the phantom analysis. We also examined the quality of the acquired clinical images using the NEC patient , NEC density , SNR liver , SUV liver and SUV lesion . Results In the phantom study on Vision scanner, RMSE was relatively lower when the iteration number was 2, 3 or 4. To satisfy a visual score of 1.5 and the reference range of Q H,10 mm / N 10mm , a 60-s or longer acquisition was required. Our clinical findings show that NEC patient averaged 17.4 ± 1.72 Mcounts/m in mCT and 29.1 ± 2.83 Mcounts/m in Vision. Furthermore, NEC density averaged 0.29 ± 0.05 kcounts/cm 3 in mCT and 0.53 ± 0.09 kcounts/cm 3 in Vision, respectively, whereas SNR liver averaged 14.6 ± 3.77% in mCT and 21.3 ± 1.69% in Vision ( P = 0.0156), respectively. Finally, SUV liver averaged 2.82 ± 0.28 and 2.55 ± 0.30, SUV lesion ranged 1.6–17.6 and 1.9–22.9 in mCT and Vision, respectively. Conclusion SiPM-PET/CT provides superior image quality and quantification accuracy compared to PMT-PET/CT.