The Myogenic Potential of Mesenchymal Stromal Cells and Their Effect on Skeletal Muscle Regeneration

The participation of mesenchymal stromal cells (MSCs) in the regeneration of muscle tissue was analyzed. It is shown that rat bone marrow MSCs do not show potency for myogenic differentiation in vitro under the influence of appropriate inducers and rarely fuse with myoblasts when co-cultured. However, the factors they release stimulate differentiation of myogenic cells. It is noted that in vivo, when combined with minced muscle tissue, MSCs enhance myogenesis and angiogenesis, and when injected into injured muscle, they improve the course of the recovery process, as well as the medium conditioned by them. The paracrine mechanism of the influence of MSCs on skeletal muscle regeneration has been established.